The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Alphavirus nsP2 protease domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Alphavirus nsP2 protease domain

Alphaviruses are a group of globally distributed positive-sense RNA viruses which infect a variety of hosts including mosquitoes, birds, rodents and other mammals. They also constitue a potential threat to human health in many areas. Their viral replication machinery comprises four non-structural proteins (nsP1-4) produced as a single polyprotein. Structural domains comprising this superfamily share the structure of the N-terminal protease domain of alphavirus protein nsP2 (nsP2pro). This protein is a cysteine protease essential for viral replication and mediates the cytopathic effects (CPE) of the virus as it mediates the cleavage of the nsP1234 polyprotein replication complex into functional components. This domain shows ATPase and GTPase activity, RNA helicase activity and RNA 5'-triphosphatase activity and contains the catalytic dyad cysteine and histidine residues organized in a protein fold that differs significantly from any known cysteine protease or protein folds PMID:23010928,PMID:27030368,PMID:16962975.

GO Diversity

Unique GO annotations
4 Unique GO terms

EC Diversity

Unique EC annotations
6 Unique EC terms

Species Diversity

Unique species annotations
48 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 7
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC: 6
Unique GO: 4
Unique Species: 48