The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
106129
25612
EC
3D
1ogqA00 - 75.6
107064
13949
EC
- - 69.3
106158
9749
EC
3D
3rgxA01 - 65.1
34970
4980
EC
3D
2o6qA00 - 68.9
106957
1615 - - 85.9
106516
1494
EC
3D
4b8cD01 - 84.6
105581
1455
3D
4rcaB00 - 90.7
106467
1297
EC
- - 80.2
106717
1250
3D
2ellA00 - 80.0
106197
Neuronal
1247
3D
4z94G02 - 89.3
22227
CH
892 - - 88.8
106223
885 - - 93.9
105975
845
EC
- - 85.2
106631
786
EC
- - 82.0
106153
764
EC
- - 94.2
105560
732
EC
3D
4lscA00 - 87.1
106854
712 - - 84.0
106804
696
EC
- - 93.6
106084
677
3D
2p1mB02 - 87.7
106132
675
EC
- - 94.0
105080
641 - - 75.8
106500
608
EC
- - 81.0
106677
606
EC
- - 93.3
105299
Drosophila
584
EC
3D
2v9sA00 - 85.5
105914
542 - - 75.1
105744
528
EC
- - 90.7
105515
Drosophila
527 - - 85.8
105365
520
EC
- - 94.4
30520
520 - - 84.6
105903
514
EC
- - 81.0
105392
Drosophila
494
3D
2v70A00 - 84.1
105404
492
3D
1xcdA00 - 83.8
105322
474
3D
1oznA00 - 89.9
105273
453
EC
- - 75.0
106966
449
EC
- - 92.8
105477
444 - - 85.6
74400
440
EC
- - 77.6
2657
440 - - 94.2
33057
434 - - 94.7
105574
418 - - 96.3
52310
393 - - 84.4
106491
391
EC
3D
4kt1A01 - 94.9
106118
389 - - 72.1
43408
342
3D
2wfhA00 - 93.7
46221
341
3D
1a9nA00 - 69.5
106780
339 - - 92.8
106039
330
3D
2id5A01 - 95.9
106205
330 - - 85.5
105792
329
EC
- - 93.6
105557
329 - - 76.6
2797
327
EC
- - 87.8
106574
325
EC
- - 77.3
4369
323 - - 82.9
106867
316
EC
3D
5b0nA00 - 76.7
106846
309
3D
5ijbA00 - 98.0
105408
302
EC
- - 64.7
4094
298
3D
3zyjA01 - 89.1
106198
297
3D
3w3gA00 - 95.7
61776
295 - - 92.6
63247
290
3D
3ogkB02 - 87.0
106624
288
3D
2z81A00 - 96.1
106445
282
EC
- - 74.2
105953
277 - - 66.3
106457
274 - - 77.6
106543
270
EC
- - 88.6
105252
266
3D
4i6jB02 - 91.0
105405
265 - - 93.6
105911
249 - - 91.5
107273
249
EC
- - 96.2
73428
247 - - 37.0
107398
245
EC
- - 83.3
41159
245 - - 74.8
105440
243
3D
5gmfA00 - 96.3
54
238
3D
4k17A03 - 94.2
105374
234
3D
3zynA00 - 82.5
105462
229 - - 93.3
106842
226
3D
1gwbA00 - 85.7
106923
217 - - 91.7
106166
216 - - 94.8
36219
216
EC
- - 72.5
106073
213
EC
- - 94.4
106629
212
EC
- - 87.6
106430
206
3D
2xotA01 - 94.1
105417
202
EC
- - 90.2
105409
202 - - 71.7
46180
200 - - 77.3
105346
200 - - 57.9
46296
197 - - 94.1
105464
197
EC
- - 78.3
106076
194
EC
- - 61.6
65334
193 - - 81.5
4289
193 - - 90.9
106442
189 - - 90.9
105369
188
EC
- - 80.3
106270
186 - - 81.1
19651
186
EC
- - 82.5
106058
185
3D
3dzeA00 - 87.6
106911
182 - - 91.0
48849
182 - - 43.1
33999
179 - - 68.9
62297
178 - - 86.9
43230
177 - - 86.3
105447
175 - - 87.3
105849
175 - - 92.4
59750
174 - - 69.2
56962
172 - - 52.5
47793
171 - - 69.1
107034
170 - - 88.0
106441
167
EC
- - 70.2
43825
164 - - 66.7
44771
Drosophila
163 - - 69.0
1998
159 - - 95.0
65333
158 - - 53.3
105500
153
3D
4v2cA00 - 68.0
3658
151
EC
3D
3g06A01 - 65.8
105509
150 - - 91.4
63969
146 - - 41.9
105306
140 - - 65.2
105580
139 - - 44.9
105411
138 - - 67.6
105687
137 - - 78.1
105177
Drosophila
136 - - 51.0
41894
134 - - 45.0
105271
132 - - 47.4
105205
132 - - 69.5
40351
131
EC
- - 83.8
5957
129 - - 82.4
106791
128 - - 79.0
105304
126
3D
2xwtC00 - 86.5
106043
125
EC
- - 87.3
106566
123
EC
- - 95.1
105737
121
3D
4qxeA01 - 88.7
105668
120 - - 63.9
14742
120
3D
4v2eA00 - 31.0
105644
119
EC
- - 74.3
55658
119 - - 50.5
105379
118 - - 74.0
105388
118 - - 44.8
51556
118
EC
- - 83.5
105570
117 - - 75.7
105207
117 - - 75.5
106449
117 - - 80.9
105449
116
EC
- - 85.3
105853
116 - - 93.6
105163
115
3D
1xwdC00 - 84.0
106855
113
3D
2z64A00 - 88.1
106694
113
3D
3a79B00 - 97.9
105213
113
3D
3wpfA00 - 76.9
105421
112
3D
1fo1A02 - 64.9
38264
109 - - 88.2
106410
109
EC
- - 75.4
105345
108 - - 92.9
106275
107 - - 71.3
39748
107 - - 84.1
61272
107 - - 14.9
105457
106 - - 61.4
34028
104 - - 81.5
106392
103
3D
4wwuB01 - 90.5
105321
103 - - 78.2
10561
102
EC
- - 11.2
29193
102 - - 63.2
106194
102 - - 57.3
106418
100 - - 79.4
106953
99
EC
3D
4hq1A02 - 95.9
107315
99
EC
- - 91.8
107137
97 - - 87.6
107039
97 - - 91.6
105418
95 - - 83.8
15063
92 - - 45.7
105829
92 - - 82.1
105910
92 - - 74.6
28963
91 - - 59.7
22573
90 - - 83.0
81123
89 - - 71.0
105528
86
EC
- - 74.6
105502
85
3D
1ziwA00 - 87.2
7921
83
EC
- - 81.2
105028
83
3D
1fqvA00 - 70.7
105406
81 - - 57.7
107268
80 - - 84.6
106908
79 - - 87.5
107191
78 - - 58.3
20322
78 - - 52.4
105677
77
EC
- - 60.3
61916
77 - - 14.7
105433
76
3D
4bsrA01 - 58.2
107212
Platelet
74
3D
3rezA00 - 77.4
105479
74 - - 58.5
105338
73 - - 63.4
105935
71 - - 77.1
87506
71 - - 62.8
5675
70 - - 71.9
17664
69 - - 67.5
562
69
3D
1w8aA00 - 74.1
105916
67 - - 75.9
106329
66 - - 87.6
105052
66 - - 44.4
1581
65 - - 10.0
105451
65 - - 84.8
105117
64 - - 52.6
105654
64 - - 71.3
51593
63 - - 14.8
106982
63 - - 90.0
55878
62 - - 59.7
105525
62 - - 94.5
2466
61 - - 66.0
105326
61 - - 76.6
44040
61 - - 55.7
106595
61
EC
- - 76.3
105503
61 - - 58.4
53939
59 - - 64.1
105276
58 - - 72.3
81266
57 - - 61.9
106738
57 - - 97.4
106411
55 - - 55.0
105375
55 - - 58.5
70076
54 - - 39.9
105426
54 - - 80.2
106065
54 - - 75.4
106231
53
EC
- - 87.5
105592
53 - - 66.2
105397
53 - - 66.5
105289
53
EC
- - 82.9
17149
52 - - 43.9
107252
51 - - 68.2
105344
51 - - 54.8
343
51
3D
1o6sA01 - 76.5
105546
50 - - 48.9
107326
50 - - 89.7
8776
49 - - 75.2
33375
49
3D
4u7lA01 - 34.4
105886
48 - - 50.9
33383
48 - - 31.4
97743
47 - - 60.8
26581
47 - - 67.1
105889
46
EC
3D
2ifgA01 - 65.7
54466
46 - - 23.3
54426
46
EC
- - 6.7
105410
46
EC
3D
1dceA03 - 51.0
44355
46 - - 48.6
54469
46 - - 81.7
106838
45 - - 86.7
105312
45
3D
5lfnA00 - 48.3
106757
44
EC
- - 75.5
37377
42 - - 58.7
84614
42 - - 58.7
105504
42 - - 82.8
43592
40 - - 92.2
105217
40
3D
4kxfB04 - 65.8
105249
40 - - 67.2
106337
39
EC
- - 72.7
2136
38 - - 42.5
105441
38
EC
- - 45.2
24280
37 - - 37.3
57453
37 - - 42.3
106180
36 - - 84.9
107095
36 - - 78.4
24894
35 - - 45.5
107084
35
EC
- - 57.0
4862
34 - - 70.4
105488
34 - - 53.6
105489
34 - - 86.7
106444
34 - - 95.8
13129
34 - - 20.7
71640
33 - - 40.9
105184
33
3D
4u7lA02 - 66.4
106894
33
EC
- - 74.2
65889
32
EC
- - 57.6
53486
31 - - 88.2
105837
31
3D
4kxfP04 - 47.8
56337
31 - - 17.2
2916
31 - - 62.3
105395
30 - - 50.3
50495
30 - - 39.2
106588
30 - - 80.0
105789
30 - - 75.2
106675
30 - - 77.8
106511
29 - - 71.8
105555
28 - - 66.8
69208
28 - - 49.6
49163
ATP pyrophosphate-lyase Adenylyl cyclase
28
EC
- - 61.9
34533
28 - - 64.2
105609
27 - - 75.0
106141
27
EC
- - 68.1
105194
27
EC
- - 42.0
45733
27
3D
4bv4R00 - 48.1
44131
26 - - 53.9
105416
26 - - 50.6
106710
26 - - 48.7
105422
25 - - 52.7
40874
25 - - 0.0
105692
25 - - 31.9
105308
25 - - 45.9
105348
24 - - 31.7
82653
23 - - 39.4
12173
23 - - 45.5
52182
22 - - 69.1
105203
22 - - 12.1
42081
22 - - 11.4
105743
21 - - 74.2
105060
21 - - 6.3
105296
21 - - 45.4
13424
21 - - 72.6
106401
21 - - 52.6
56599
20 - - 33.7
106419
20 - - 46.3
53572
20
EC
- - 45.7
105102
20 - - 40.5
19715
19 - - 39.5
56322
19 - - 17.4
106405
19 - - 75.9
106734
18 - - 50.1
9995
18 - - 52.1
105280
17 - - 59.1
105907
17 - - 74.3
19191
17 - - 21.3
10364
17 - - 21.8
68740
17 - - 24.7
55011
16 - - 28.0
13378
16 - - 46.7
54316
16 - - 41.6
106573
16 - - 42.7
11281
15 - - 25.4
27494
15 - - 45.0
105490
15 - - 47.2
31663
15
3D
1g9uA00 - 12.1
46851
15 - - 20.0
106816
15 - - 37.7
11736
15
EC
- - 1.3
75414
15 - - 49.0
106236
14 - - 45.6
83754
14 - - 22.9
5392
14 - - 52.0
66043
14 - - 49.5
13444
14 - - 38.3
553
14
3D
3bz5A01 - 2.7
44014
14 - - 71.4
67799
13 - - 26.0
105871
13 - - 47.8
91773
13 - - 10.5
24820
13 - - 1.5
69881
13 - - 74.3
107337
13 - - 79.6
48817
13 - - 35.3
105263
13 - - 21.8
105381
LPXTG motif
12 - - 24.9
105156
12 - - 78.4
69089
12 - - 42.3
18529
12 - - 27.0
85819
12 - - 66.9
65705
12 - - 49.8
106565
12 - - 76.2
106928
12 - - 53.2
30385
12
EC
- - 20.9
22329
12 - - 24.8
33035
12 - - 19.3
16511
11 - - 41.6
40668
11 - - 37.0
53159
11 - - 46.5
66418
11 - - 28.4
19452
11 - - 28.7
89994
11 - - 28.8
28091
11
EC
- - 9.3
38917
11 - - 30.3
105196
11
EC
- - 20.7
106546
11 - - 45.1
107153
11 - - 78.1
52166
11 - - 25.9
4724
11 - - 21.6
105049
11 - - 15.4
52262
11 - - 24.7
105174
10 - - 15.8
107409
10 - - 6.0
106436
10 - - 79.0
55877
10
3D
4lxrA02 - 7.9
3049
10 - - 35.6
105399
10 - - 46.6
22714
10 - - 15.9
46223
9 - - 9.3
106387
Eurofung
9 - - 1.6
26705
9 - - 19.4
53920
9
EC
- - 18.1
39255
9 - - 35.9
62449
9 - - 29.0
106128
9 - - 65.5
105526
9 - - 40.3
107380
9
EC
- - 73.2
52852
9 - - 21.4
27418
9 - - 12.3
68515
9 - - 19.2
74692
8 - - 10.9
107205
8 - - 54.7
38150
8 - - 38.6
69108
8 - - 11.8
105920
8 - - 29.1
106326
8
EC
- - 43.4
44359
8
EC
- - 16.2
107221
8 - - 58.2
82264
8 - - 26.7
106740
8 - - 43.0
66419
8 - - 19.8
57419
8 - - 26.5
58053
TIR-NBS-LRR class
8 - - 32.5
14451
8 - - 18.9
42152
7 - - 26.2
20893
7 - - 23.0
55355
7 - - 22.8
106517
7 - - 36.9
69036
7 - - 36.4
37674
7
3D
1ds9A00 - 8.3
18759
7 - - 49.4
49921
7 - - 44.0
38936
7 - - 3.4
19298
7 - - 3.0
107178
7 - - 39.9
107433
7 - - 59.0
106038
7 - - 12.8
50212
7 - - 13.1
105438
7 - - 27.8
53357
7
EC
- - 12.5
56022
6 - - 25.4
90765
6 - - 34.5
49423
6 - - 18.3
51206
6 - - 16.4
74857
6
EC
- - 4.9
851
6 - - 0.0
105255
6 - - 9.2
57040
6 - - 8.6
48373
6 - - 15.8
84678
6 - - 22.1
106014
6 - - 17.8
106558
6 - - 6.3
26113
6 - - 8.0
39392
6 - - 3.4
57079
6 - - 13.2
30176
6
EC
- - 1.4
8396
6
EC
3D
4hq1A01 - 5.0
59147
5 - - 36.1
33738
5 - - 16.1
106386
5 - - 22.6
20310
5 - - 0.0
4395
5 - - 10.1
105982
5 - - 44.7
90812
5 - - 10.0
9068
5 - - 11.2
4531
5 - - 9.5
26212
5 - - 3.6
2305
5 - - 11.8
28887
5 - - 10.6
53700
5
EC
- - 9.8
67007
5 - - 13.8
77939
5 - - 0.0
48870
5 - - 11.1
106837
5 - - 46.5
75353
5 - - 45.3
105776
5 - - 41.4
51207
5
EC
- - 28.7
45039
5
EC
- - 7.5
70682
5 - - 19.8
106871
5 - - 12.8
94597
5 - - 26.3
106678
5
EC
- - 20.6
107244
4 - - 0.0
46682
4 - - 17.4
54274
4 - - 0.0
23059
LRR
4 - - 7.2
105971
4 - - 0.0
8170
4 - - 37.5
31609
4 - - 12.4
19562
4 - - 0.0
105243
4 - - 27.4
47967
4 - - 14.9
106580
4 - - 50.1
105396
4
EC
- - 0.0
106134
4 - - 17.1
77313
4 - - 13.8
105235
4 - - 20.3
106539
4 - - 0.5
21684
4 - - 0.0
11044
4 - - 15.6
65951
4 - - 20.4
90036
4
EC
- - 0.0
42504
4 - - 15.9
106374
4 - - 32.1
107189
4
EC
- - 50.9
105536
4 - - 32.2
29977
4 - - 12.5
77797
4 - - 16.3
50708
4
3D
3jb9j00 - 17.4
1480
4 - - 28.3
106581
3 - - 12.1
57114
3 - - 0.0
6158
3 - - 30.9
50707
3
EC
- - 13.3
52607
3
EC
- - 4.3
73639
3 - - 17.5
78393
3 - - 6.4
76227
3 - - 17.0
27168
3 - - 5.7
98271
3 - -
105118
3 - - 13.6
30785
3 - - 0.0
49992
3
EC
- - 4.7
11203
3 - - 8.0
17971
3 - - 3.8
106424
3 - - 28.0
42416
3 - - 15.9
106578
3 - - 19.5
84549
3 - - 4.4
105193
3 - - 11.6
17904
3 - - 0.0
105465
3 - - 34.6
105863
3 - - 0.0
16942
3 - - 10.4
105362
3 - - 0.0
38159
3 - - 22.8
89350
3 - - 7.2
56196
3 - - 12.0
40454
3 - - 22.4
51621
3
EC
- - 15.1
47587
3 - - 6.5
106936
3 - - 38.9
105793
2 - - 29.8
47139
2
EC
- - 7.5
56414
2 - - 0.8
4794
2 - - 0.0
67221
2 - - 3.9
39237
2 - - 14.9
105471
2
EC
- - 0.0
8344
2 - - 12.6
38757
2 - - 0.0
106625
2 - -
72231
2 - - 6.8
31598
2 - - 0.0
13852
2 - - 7.5
106009
2 - - 0.0
34241
2 - - 16.2
59052
2 - - 8.9
80107
2 - - 0.0
82867
2 - - 8.6
13078
2 - - 13.0
7260
2 - - 9.3
94599
2 - - 5.0
107238
2 - - 0.0
61715
2 - - 0.0
107170
2 - - 35.6
3328
2 - - 0.0
41583
2 - - 11.7
106156
2 - - 18.5
53695
2 - - 3.4
38912
2 - - 4.4
105768
2 - -
55047
2 - - 0.8
107419
2 - - 14.9
87340
2 - - 7.6
106997
2 - - 1.5
65387
2 - - 0.9
7486
2 - - 0.0
69314
2 - - 10.4
106696
2
EC
- - 22.4
101166
2 - - 18.4
22230
2 - - 5.2
82426
2 - - 0.0
21143
2 - - 16.3
36874
2 - - 8.4
84243
2 - - 0.0
35317
2 - - 1.9
6361
1 - - 0.0
56868
1 - -
106728
1 - - 0.0
43053
1 - - 0.0
3984
1 - - 0.0
81508
1 - - 0.0
46166
1 - - 0.0
106748
1 - - 0.0
51596
1 - - 0.0
106238
1 - - 0.0
105302
1 - - 0.0
92274
1 - - 0.0
106932
1 - - 0.0
76601
1 - - 0.0
92760
1 - - 0.0
79931
1
EC
- - 0.0
76207
1 - - 0.0
55875
1 - - 0.0
28482
1 - - 0.0
100937
1 - -
51134
1 - - 0.0
107287
1 - - 0.0
67928
1 - - 0.0
1320
1 - - 0.0
55879
1 - - 0.0
11248
1 - - 0.0
8544
1
EC
- - 0.0
106331
1 - -
3572
1 - - 0.0
106242
1 - - 0.0
4562
1 - - 0.0
22589
1 - - 0.0
96732
1 - - 0.0
43532
1 - - 0.0
107171
1 - - 0.0
61678
1 - - 0.0
94814
1 - - 0.0
5058
1 - - 0.0
64872
1
EC
- - 0.0
105324
1 - - 0.0
105999
1 - - 0.0
93414
1 - - 0.0
53152
1 - - 0.0
23247
1 - - 0.0
106472
1 - - 0.0
30499
1 - - 0.0
62160
1 - -
105303
1 - - 0.0
50160
1 - -
77907
1 - - 0.0
106701
1 - - 0.0
57803
1
EC
- - 0.0
107176
1 - - 0.0
43385
1 - - 0.0
106811
1 - - 0.0
106286
1
EC
- - 0.0
58518
1 - - 0.0
61180
1 - - 0.0
34680
1 - - 0.0
75863
1 - - 0.0
56012
1 - - 0.0
92235
1 - - 0.0
103725
1 - - 0.0
8617
1 - - 0.0
95677
1 - - 0.0
106045
1 - - 0.0
55098
1 - - 0.0
52330
1 - - 0.0
60675
1
EC
- - 0.0
57947
1 - - 0.0
4681
1 - - 0.0
60089
1 - - 0.0
44112
1 - - 0.0
106775
1 - - 0.0
107246
1 - - 0.0
58463
1 - - 0.0
106184
1 - - 0.0
75999
1 - - 0.0
105446
1 - - 0.0
10261
1 - - 0.0
56432
1 - - 0.0
107029
1 - - 0.0
51374
1 - - 0.0
62154
1 - -
39058
1 - - 0.0
38487
1 - - 0.0
68854
1 - - 0.0
23797
1 - - 0.0
5248
1 - - 0.0
106190
1 - - 0.0
66417
1 - - 0.0
16593
1 - - 0.0
52608
1 - - 0.0
2921
1 - - 0.0
14785
1 - - 0.0
21139
1 - - 0.0
64325
1 - - 0.0
107397
1 - - 0.0
41965
1 - - 0.0
77371
1 - -
76348
1 - -
26136
1 - -
94794
1 - -
45812
1 - - 0.0
106420
1
EC
- - 0.0
63431
1 - - 0.0
101853
1 - - 0.0
22235
1 - - 0.0
24391
1 - - 0.0
57286
1 - - 0.0
57752
1 - - 0.0
72780
1 - - 0.0
31928
1 - -
106201
1 - - 0.0