The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Sec1/Munc18 (SM) protein, domain 2

This superfamily entry represents domain 2 which is well conserved across SM protein structures, such as Munc18-2, Vps33A. Members of the Sec1 family include Sec1, Sly1, Slp1/Vps33, Vps45/Stt10 (yeast), Unc-18 (nematode), Munc-18b/muSec1, Munc-18c (mouse), Rop (Drosophila), Munc-18/n-Sec1/rbSec1A and rbSec1B (rat) PMID:8769846. The Sec1/Munc18 protein family contains proteins associated with vesicle transport, regulating these processes by binding to t-SNARE homologues of syntaxin with high affinity. Linked to this superfamily are syntaxin-binding protein FunFams. In eukaryotic cells, the movement of macromolecules between their membrane-bound compartments is a highly regulated process controlled by multi-subunit protein sorting complexes. The mammalian HOPS complex is one such example and it comprises six subunits (Vps11, Vps16, Vps18, Vps33A, Vps39, and Vps41). Human Vps33A is predicted to be a member of the Sec1/Munc18 (SM) family of proteins that, together with SNAREs, comprise the core machinery essential for membrane fusion in eukaryotes.

INTERPRO:IPR027482, INTERPRO:IPR036045, PFAM:PF00995,PMID:8769846,PMID:23901104,PMID:24194549,PMID:21876177,PMID:12426383,DOI:10.1016/S0969-2126(00)00156-8

GO Diversity

Unique GO annotations
220 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1629 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 29
Domain clusters (>95% seq id): 8
Domain clusters (>35% seq id): 4
Unique PDBs: 20
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 40
Function
Unique EC:
Unique GO: 220
Taxonomy
Unique Species: 1629