The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Kinesin-like protein Kif23, Arf6-interacting domain

Cytokinesis is the final stage of cell division, were the cells exhibit drastic morphological changes and remodelling of the cytoskeleton. In anaphase/telophase, an actomyosin contractile ring constricts the plasma membrane in the equatorial region of a dividing cell to form a cleavage furrow, whilst an overlapping region of antiparallel microtubules from the central spindle gradually forms a dense structure in the middle of the intercellular bridge, the so-called Flemming body.

Structural domains comprising this superfamily share the structure of Arf6, a small GTPase which participates in cytokinesis by localizing to the Flemming body (the midbody). Arf6 directly interacts with mitotic kinesin-like protein 1 (MKLP1), a Flemming body-localizing protein essential for cytokinesis. The Arf6-MKLP1 complex plays a crucial role in cytokinesis by connecting the microtubule bundle and membranes at the cleavage plane PMID:22522702.

GO Diversity

Unique GO annotations
56 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
300 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 1
Unique GO: 56
Unique Species: 300