The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CDGSH iron-sulfur domain, mitoNEET-type

The recently discovered CDGSH iron-sulfur domains (CISDs) are classified into seven major types and are widely distributed throughout the three domains of life PMID:21949752. Members of this superfamily share the structure of the human CISD protein mitoNEET, also designated CSD1, an iron-containing integral protein of the outer mitochondrian membrane (OMM). MitoNEET contains two domains: a beta-cap region and a cluster-binding domain, containing the CDGSH motif, that coordinates two acid-labile 2Fe-2S clusters (one bound to each protomer) PMID:17766440. The CDGSH iron-sulphur domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, (INTERPRO:IPR019610) PMID:17584744,PMID:17766440. The whole protein regulates oxidative capacity and might be involved in electron transfer.

GO Diversity

Unique GO annotations
22 Unique GO terms

EC Diversity

Unique EC annotations
8 Unique EC terms

Species Diversity

Unique species annotations
3008 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 50
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 4
Unique PDBs: 17
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 8
Unique GO: 22
Unique Species: 3008