The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein S6/Translation elongation factor EF1B

This superfamily includes a structural domain found in the ribosomal protein S6 from the small (30S) subunit of the ribosome, and in the translation elongation factor EF1B. This entry also includes homologues such as beta-AP (Alzheimer beta-peptide), PilO (a membrane protein involved in the assembly of pilin in T4P, type 4 pili INTERPRO:IPR007445), bacterial, red algal chloroplast and cyanelle S6 ribosomal proteins. Structurally it is an alpha+beta sandwich domain (four-stranded antiparallel beta-sheets flanked by two alpha-helices) and exhibits a Ferredoxin-like fold.

Folding of the ribosomal protein S6 is a malleable process controlled by two competing, and partly overlapping, folding nuclei. The structure of S6 is composed of two cooperative subunits or 'foldons', sigma1 and sigma2, that also act as competing nuclei in the folding process. PMID:22117065. In E. coli, ribosomal protein S6 is known to bind 16S rRNA, together with S18.

Elongation factor eEF1B alpha (also known as EF1B, EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta).

In P. aeruginosa, PilM/N/O/P proteins are essential for T4P biogenesis, the periplasmic domains of PilN and PilO interact to form a heterodimer. PilO was shown to play a key role in the proper folding of PilN.

PFAM:PF01250, INTERPRO:IPR014717, INTERPRO:IPR035980,PMID:11106763,PMID:10944185,PMID:22117065,PMID:12762045

GO Diversity

Unique GO annotations
67 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
19438 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 382
Domain clusters (>95% seq id): 15
Domain clusters (>35% seq id): 9
Unique PDBs: 373
Structural Clusters (5A): 3
Structural Clusters (9A): 2
FunFam Clusters: 50
Unique EC:
Unique GO: 67
Unique Species: 19438