The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CRISPR-associated endoribonuclease Cas6/Csy4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CRISPR-associated endoribonuclease Cas6/Csy4

This protein family is typified by YPO2462 of Yersinia pestis and it is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4. crRNA biogenesis in Pseudomonas aeruginosa requires the endoribonuclease Csy4, which binds and cleaves the repetitive sequence of the CRISPR transcript PMID:22522703. The crystal structure of Csy4 in complex with its cognate RNA reveals an unexpected recognition mechanism whereby Csy4 makes sequence-specific interactions in the major groove of the CRISPR repeat stem-loop. Together with electrostatic contacts to the phosphate backbone, these enable Csy4 to selectively bind and cleave pre-crRNAs PMID:20829488.

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
617 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 11
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 10
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 617