The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Translational regulator CsrA

Structural domains comprising this sueprfamily share the structure of the highly conserved bacterial translational regulator protein CsrA. This RNA-binding protein acts by regulating translation and stability of mRNAs which code for proteins involved in metabolism and virulence PMID:23954502. CsrA is a dimer of two identical subunits, each composed of five strands, a small alpha-helix and a flexible C terminus.

CsrA destabilizes target mRNAs by binding in a region within the -18 and +31 nucleotides of the coding region, which includes the ribosome-binding site. This prevents translation of the corresponding mRNA and promotes its degradation by endogenous RNases. The intracellular levels of CsrA are regulated by two untranslated RNA molecules, CsrB and CsrC, that act as antagonists by sequestering CsrA and preventing its binding to target mRNAs PMID:15866937. .

GO Diversity

Unique GO annotations
13 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
4499 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 5
Unique GO: 13
Unique Species: 4499