The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Ncd80 complex, Spc24 subunit

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ncd80 complex, Spc24 subunit

The name has been assigned the fact that the representative domain for this superfamily maps extremely well to a Pfam domain which belongs to a family known as Spc24. According to the literature PMID:18455984 Spc24 is one of the four subunits of the Ndc80 complex, an essential component of kinetochores since it comprises a point of direct contact between kinetochores and microtubules that make up the mitotic spindle and therefore has a key role in chromosome segregation.

There seemed to be an incongruity in the PDBe sequence viewer which showed how in both Pfam and InterPro this domain corresponds to Spc25, another subunit of the Ndc80 complex. Spc24 render more appropriate since the publication associated with the given PDB which contains domains in this superfamily clearly shows that this representative domain corresponds to Spc24.

GO Diversity

Unique GO annotations
9 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
258 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC:
Unique GO: 9
Unique Species: 258