The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Phosphoribosyl-AMP cyclohydrolase

Structural domains comprising this superfamily share the structure of phosphoribosyl-AMP cyclohydrolase (PR-AMP), product of hisI gene which catalyses the first step in histidine biosynthesis. This metabolic pathway is of great interest from an evolutionary point of view due to the diversity of gene organizations and protein structures. One example of such diversity comes from the HisI gene, which can exist alone or as a fusion with hisE.

The structure of the HisI catalytic site is consistent with a reaction mechanism similar to those of nucleoside deaminases and both Zn2+ and Mg2+ are both key players in the catalytic mechanism PMID:16042384.

GO Diversity

Unique GO annotations
14 Unique GO terms

EC Diversity

Unique EC annotations
9 Unique EC terms

Species Diversity

Unique species annotations
10841 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 9
Unique GO: 14
Unique Species: 10841