The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Fungal immunomodulatory protein Fve

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Fungal immunomodulatory protein Fve

Structural domains comprising this superfamily share the structure of FIP-Fve (Fungal Immunomodulatory Protein Fve), a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity PMID:7705335. It is involved in several different processes including the stimulation lymphocyte mitogenesis, suppression of systemic anaphylaxis reactions and oedema, enhancement of the transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutination of red blood cells. It is believed to be a lectin with specificity for complex cell-surface carbohydrates.

Fve adopts a tertiary structure consisting of an immunoglobulin-like beta-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer and dimerisation occurs by 3-D domain swapping of the N-terminal helices and is mainly stabilised by hydrophobic interactions PMID:12948495.

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
46 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 5
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC:
Unique GO:
Unique Species: 46