The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: F-actin capping protein, beta subunit

The F-actin capping protein is a heterodimer composed of two unrelated alpha and beta subunits. Neither of the subunits shows sequence similarity to other filament-capping proteins PMID:2341404.

This superfamily represents the beta subunit of F-actin capping protein (CAPZB), a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species PMID:2179733. In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration PMID:16143599. In humans CAPZB is part of the WASH complex that controls the fission of endosomes PMID:19922875.

INTERPRO:IPR001698,PFAM:PF01115

GO Diversity

Unique GO annotations
74 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
1214 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 66
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 2
Unique PDBs: 16
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 3
Unique GO: 74
Taxonomy
Unique Species: 1214