The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nsp8 replicase, head domain

This superfamily consists of 3 alpha helices and 7 beta strands.

The 7 beta strands form an open barrel, with 2 anti-parallel beta strands perpendicular to the barrel (orthogonally). Within Nsp8I/II, this domain has a tight hydrophobic core.

In nature, Nsp8I and Nsp8II interact with Nsp7 to form two distinct heterodimers (D1: Nsp8I/Nsp7 and D2: Nsp8II/Nsp7). Which ultimately form a hexadecameric supercomplex.

GO Diversity

Unique GO annotations
29 Unique GO terms

EC Diversity

Unique EC annotations
6 Unique EC terms

Species Diversity

Unique species annotations
292 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 6
Unique GO: 29
Unique Species: 292