The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Y-family DNA polymerase, catalytic domain, fingers subdomain

Polymerases belonging to the Y family are the main enzymes that help cells tolerate DNA damage, by allowing DNA synthesis to continue across from lesions that stall replicative polymerases PMID:23245850. They are divided into six major groups based on amino acid sequence. They are represented by E. coli pol IV (known as DinB) and pol V (of which UmuC is the catalytic subunit) and four human enzymes, pol eta, iota, kappa, and Rev1 PMID:24716551. The Y-family polymerases contain two domains that are required for full polymerase activity: an N-terminal catalytic polymerase domain (comprised of fingers, palm, and thumb subdomains); and a C-terminal "little fingers" or polymerase-associated domain (LF/PAD) that assists with binding DNA PMID:23245850. This entry represents the fingers domain which exhibits an alpha/beta fold.

PMID:23245850 PMID:24716551

GO Diversity

Unique GO annotations
55 Unique GO terms

EC Diversity

Unique EC annotations
13 Unique EC terms

Species Diversity

Unique species annotations
12699 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 389
Domain clusters (>95% seq id): 10
Domain clusters (>35% seq id): 7
Unique PDBs: 313
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 13
Unique GO: 55
Unique Species: 12699