The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CarD-like/TRCF, N-terminal domain

Structural domains comprising this superfamily share the structure of the all beta-stranded N-terminal domain of CarD from Mycobacterium tuberculosis (Mtb), an essential protein thought to be involved in stringent response through down-regulation of rRNA and ribosomal protein genes. CarD interacts with the beta-subunit of RNAP through its N-terminal domain with this interaction being vital for Mtb's survival during the persistent infection state. The structural fold of the CarD N-terminal domain is conserved in RNAP interacting proteins, such as TRCF.

CarD is DNA binding protein but the N-terminal domain is not involved in this process and mutation studies have revealed that the C-terminal domain is the DNA interaction domain.

GO Diversity

Unique GO annotations
19 Unique GO terms

EC Diversity

Unique EC annotations
7 Unique EC terms

Species Diversity

Unique species annotations
11938 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 11
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 6
Unique PDBs: 8
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 7
Unique GO: 19
Unique Species: 11938