The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Plus-3 domain

The yeast Paf1 complex consists of Pfa1, Rtf1, Cdc73, Ctr9, and Leo1. The complex regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. Structural domains comprising this superfamily share the structure of the conserved and functionally important Plus3 domain of human Rtf1. This predominantly beta-stranded subdomain displays structural similarity to Dicer/Argonaute PAZ domains and Tudor domains. The plus-3 domain spans the most conserved regions of the Rtf1 protein and is surrounded by regions of low complexity and coiled-coil propensity PMID:11014804. It contains a limited number of highly conserved amino acids, three of which are positively charged residues, reason behind this domains name. Plus3 Is structurally and functionally related to other nucleic acid binding domains and its capacity to bind single-stranded DNA is at least one of the functions of the Plus3 domain PMID:18184592.

GO Diversity

Unique GO annotations
59 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
1083 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 3
Unique GO: 59
Unique Species: 1083