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CATH Superfamily 1.20.50.60

ESP1, core domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
ESP1, core domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ESP1, core domain

This superfamily is represented by ESP1 (exocrine gland-secreting peptide 1), a sex pheromone that is released in male mouse tear fluids and enhances female sexual receptive behaviour. ESP1 is selectively recognised by a specific class C G-protein-coupled receptor (GPCR), V2Rp5, among the hundreds of receptors expressed in vomeronasal sensory neurons (VSNs). The peptides are short, all carrying an N-terminal signal peptide to indicate they are for secretion which accounts for much of the common conservation.

ESP1 consists of three helices with an overall helical fold stabilised by an intramolecular disulfide bridge.

PFAM:PF16590, INTERPRO:IPR032253,DOI:10.1074/jbc.M112.436782

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
3 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 3
Taxonomy
Unique Species: 3