The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: MukB, hinge domain

Structural domains comprising this superfamily share the structure of the hinge domain of E. coli's chromosome partition protein MukB, homologous to the SMC (structural maintenance of chromosomes) protein found in eubacteria. Recent studies have shown that MukB and topo IV interact physically and that MukB can stimulate the ability of topo IV to relax negatively supercoiled DNA. This hinge domain, also known as dimerisation domain, is not only involved in dimerization, but it has also been implicated in both conformational flexibility and dynamic protein-DNA interactions PMID:19853611,PMID:20034111,PMID:24097060.

GO Diversity

Unique GO annotations
11 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
996 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 5
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 3
Unique GO: 11
Unique Species: 996