The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PriA, 3(prime) DNA-binding domain

Primosomal protein N', also known as ATP-dependent helicase PriA, is a component of the primosome, involved in replication, repair and recombination. PriA is a multifunctional enzyme that mediates the essential process of restarting prematurely terminated DNA replication reactions in bacteria PMID:17483094,PMID:23264623. PriA presents a two-domain architecture, with an N-terminal DNA-binding domain (DBD) and a C-terminal helicase domain (HD). Structural studies reveal a central helicase core surrounded by an array of DNA-binding elements. These elements include two domains within the DBD, a 3(prime) DNA-binding domain (3primeBD) and an unusual circularly permuted winged helix (WH) domain, and two domains within the HD, a Cys-rich region (CRR) that binds two Zn2+ ions and a C-terminal domain (CTD) which shows unexpected similarity to the S10 subunit of the bacterial ribosome PMID:24379377. Structural domains comprising this superfamily share the structure of the 3(prime) DNA binding domain.

GO Diversity

Unique GO annotations
18 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
11688 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 25
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 7
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 3
Unique GO: 18
Unique Species: 11688