The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain

Structural domains comprising this superfamily share the structure of the N-terminal subdomain of the C-terminal domain of the exocyst complex subunit Sec15. The exocyst is important for exocytosis in yeast and is required for targeting and docking vesicles to specific membrane sites during budding. The exocyst is evolutionarily conserved from yeast to human. The yeast exocyst is found in sites where active exocytosis and membrane addition take place, and functions as an effector of Sec4p, a vesicle-associated Rab GTPase. Sec15p links Sec4p and downstream fusion effectors at discrete cellular locations. Its C-terminal domain mediates Rab GTPases binding which occurs in a GTP-dependent manner PMID:16155582.

GO Diversity

Unique GO annotations
40 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1275 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 20
Unique EC:
Unique GO: 40
Unique Species: 1275