The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

MRG domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: MRG domain

The mortality family of transcription factors (MORF) comprises three proteins, two of which (MRG15 and MRGX) promote cell proliferation while the third, MORF4, is involved in replicative senescence PMID:22244764. These are localized to the nucleus and have predicted motifs that indicate they function as chromatin remodelling complex components. Even though MORF4, MRG15 and MRGX have a different N-terminal part, they share a common C-terminal part, the MRG domain whose structure is shared by members of this superfamily. This domain is involved in the binding of a plethora of transcriptional regulators and chromatin-remodeling factors, such as the histone deacetylase transcriptional co-repressor mSin3A and the nuclear protein PAM14 (protein-associated MRG, 14kDa) PMID:9891081,PMID:11290425,PMID:22244764.

GO Diversity

Unique GO annotations
58 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1370 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 13
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 7
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 39
Unique EC:
Unique GO: 58
Unique Species: 1370