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CATH Superfamily 1.10.1220.160

DNA sulphur modification protein DndE

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DNA sulphur modification protein DndE
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DNA sulphur modification protein DndE

Structural domains comprising this superfamily share the structure of DndE, a member of the highly conserved gene cluster dndA/iscS-dndBCDE that is widespread across bacterial and archaeal species involved in DNA phosphorothioation (PT). PT is a type of DNA backbone modification where a non-bridging oxygen atom of the phosphodiester bond is replaced with a sulfur atom in Rp (rectus for plane) configuration PMID:26539172. DndE is neither a sulfotransferase nor a NCAIR synthase analogue, but a possible nicked dsDNA binding protein, process which might be essential for DNA PT modification PMID:22525332.

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
624 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 20
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO:
Taxonomy
Unique Species: 624