CATH Classification

Domain Context

CATH Clusters

Superfamily Sulfite Reductase Hemoprotein, domain 1
Functional Family Sulfite reductase [NADPH] hemoprotein beta-component

Enzyme Information

1.8.1.2
Assimilatory sulfite reductase (NADPH).
based on mapping to UniProt P17846
H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.
-!- The enzyme, which catalyzes the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast. -!- Different from EC 1.8.99.5, which is involved in prokaryotic sulfur- based energy metabolism. -!- Formerly EC 1.8.99.1.

UniProtKB Entries (1)

P17846
CYSI_ECOLI
Escherichia coli K-12
Sulfite reductase [NADPH] hemoprotein beta-component

PDB Structure

PDB 8GEP
External Links
Method X-RAY DIFFRACTION
Organism Salmonella
Primary Citation
Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products.
Crane, B.R., Siegel, L.M., Getzoff, E.D.
Biochemistry