CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38
Cathepsin K.
based on mapping to UniProt P43235
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235
CATK_HUMAN
Homo sapiens
Cathepsin K

PDB Structure

PDB 7PCK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of wild-type human procathepsin K.
Sivaraman, J., Lalumiere, M., Menard, R., Cygler, M.
Protein Sci.