CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P09945
HIRV2_HIRME
Hirudo medicinalis
Hirudin variant-2

PDB Structure

PDB 6EO9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
How a beta-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
Belviso, B.D., Caliandro, R., de Candia, M., Zaetta, G., Lopopolo, G., Incampo, F., Colucci, M., Altomare, C.D.
J. Med. Chem.