CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P9WGZ1
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P9WGY5
RPOZ_MYCTU
Mycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit omega

PDB Structure

PDB 6EE8
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Boyaci, H., Chen, J., Jansen, R., Darst, S.A., Campbell, E.A.
Nature