CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1410 | Poly(a)-polymerase, middle domain |
|
1.10.1410.40 |
Domain Context
CATH Clusters
| Superfamily | 1.10.1410.40 |
| Functional Family | Cyclic GMP-AMP synthase |
Enzyme Information
| 2.7.7.86 |
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8N884
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
|
UniProtKB Entries (1)
| Q05066 |
SRY_HUMAN
Homo sapiens
Sex-determining region Y protein
|
PDB Structure
| PDB | 6EDB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA
|