CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I, domain 4
Functional Family DNA topoisomerase 1

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt P9WG49
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

P9WG49
TOP1_MYCTU
Mycobacterium tuberculosis H37Rv
DNA topoisomerase 1

PDB Structure

PDB 6CQ2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.
Cao, N., Tan, K., Annamalai, T., Joachimiak, A., Tse-Dinh, Y.C.
Nucleic Acids Res.