CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cyclin-G-associated kinase isoform X1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14976
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14976
GAK_HUMAN
Homo sapiens
Cyclin-G-associated kinase

PDB Structure

PDB 5Y7Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.
Ohbayashi, N., Murayama, K., Kato-Murayama, M., Kukimoto-Niino, M., Uejima, T., Matsuda, T., Ohsawa, N., Yokoyoma, S., Nojima, H., Shirouzu, M.
ChemistryOpen