CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10860 | Leucine Dehydrogenase, chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Leucine Dehydrogenase, chain A, domain 1 |
| Functional Family |
Enzyme Information
| 1.5.1.15 |
Methylenetetrahydrofolate dehydrogenase (NAD(+)).
based on mapping to UniProt P13995
5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
| 3.5.4.9 |
Methenyltetrahydrofolate cyclohydrolase.
based on mapping to UniProt P13995
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
|
UniProtKB Entries (1)
| P13995 |
MTDC_HUMAN
Homo sapiens
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
|
PDB Structure
| PDB | 5TC4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Cancer Res.
|