CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase Rpb2, domain 2
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P22138
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P32529
RPA12_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase I subunit RPA12

PDB Structure

PDB 5M5X
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Molecular Structures of Transcribing RNA Polymerase I.
Tafur, L., Sadian, Y., Hoffmann, N.A., Jakobi, A.J., Wetzel, R., Hagen, W.J., Sachse, C., Muller, C.W.
Mol. Cell