CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family serine/threonine-protein kinase Nek2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P51955
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P51955
NEK2_HUMAN
Homo sapiens
Serine/threonine-protein kinase Nek2

PDB Structure

PDB 5M53
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-guided design of purine-based probes for selective Nek2 inhibition.
Coxon, C.R., Wong, C., Bayliss, R., Boxall, K., Carr, K.H., Fry, A.M., Hardcastle, I.R., Matheson, C.J., Newell, D.R., Sivaprakasam, M., Thomas, H., Turner, D., Yeoh, S., Wang, L.Z., Griffin, R.J., Golding, B.T., Cano, C.
Oncotarget