CATH Classification

Domain Context

CATH Clusters

Superfamily Golgi alpha-mannosidase II
Functional Family

Enzyme Information

2.4.1.-
Hexosyltransferases.
based on mapping to UniProt P04062
3.2.1.104
Steryl-beta-glucosidase.
based on mapping to UniProt P04062
Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
-!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
3.2.1.45
Glucosylceramidase.
based on mapping to UniProt P04062
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
-!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).

UniProtKB Entries (1)

P04062
GLCM_HUMAN
Homo sapiens
Lysosomal acid glucosylceramidase

PDB Structure

PDB 5LVX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
beta-Glucocerebrosidase Modulators Promote Dimerization of beta-Glucocerebrosidase and Reveal an Allosteric Binding Site.
Zheng, J., Chen, L., Skinner, O.S., Ysselstein, D., Remis, J., Lansbury, P., Skerlj, R., Mrosek, M., Heunisch, U., Krapp, S., Charrow, J., Schwake, M., Kelleher, N.L., Silverman, R.B., Krainc, D.
J. Am. Chem. Soc.