CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P20248
CCNA2_HUMAN
Homo sapiens
Cyclin-A2

PDB Structure

PDB 5LMK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.
Hylsova, M., Carbain, B., Fanfrlik, J., Musilova, L., Haldar, S., Kopruluoglu, C., Ajani, H., Brahmkshatriya, P.S., Jorda, R., Krystof, V., Hobza, P., Echalier, A., Paruch, K., Lepsik, M.
Eur J Med Chem