CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 5KA0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Choy, M.S., Li, Y., Machado, L.E., Kunze, M.B., Connors, C.R., Wei, X., Lindorff-Larsen, K., Page, R., Peti, W.
Mol. Cell