CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P0DPI1
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A
Q496J9
SV2C_HUMAN
Homo sapiens
Synaptic vesicle glycoprotein 2C

PDB Structure

PDB 5JLV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Yao, G., Zhang, S., Mahrhold, S., Lam, K.H., Stern, D., Bagramyan, K., Perry, K., Kalkum, M., Rummel, A., Dong, M., Jin, R.
Nat.Struct.Mol.Biol.