CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family

Enzyme Information

2.3.1.47
8-amino-7-oxononanoate synthase.
based on mapping to UniProt Q146K3
Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
-!- The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. -!- Pimeloyl-CoA can be used with lower efficiency.

UniProtKB Entries (1)

Q146K3
BIOF_PARXL
Paraburkholderia xenovorans LB400
8-amino-7-oxononanoate synthase

PDB Structure

PDB 5JAY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of an 8-amino-7-oxononanoate Synthase from Burkholderia xenovorans
Dranow, D.M., Conrady, D.G., Lorimer, D., Edwards, T.E.
to be published