CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family GDP-mannose 4,6 dehydratase

Enzyme Information

4.2.1.47
GDP-mannose 4,6-dehydratase.
based on mapping to UniProt O60547
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
-!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.

UniProtKB Entries (1)

O60547
GMDS_HUMAN
Homo sapiens
GDP-mannose 4,6 dehydratase

PDB Structure

PDB 5IN4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
Allen, J.G., Mujacic, M., Frohn, M.J., Pickrell, A.J., Kodama, P., Bagal, D., San Miguel, T., Sickmier, E.A., Osgood, S., Swietlow, A., Li, V., Jordan, J.B., Kim, K.W., Rousseau, A.C., Kim, Y.J., Caille, S., Achmatowicz, M., Thiel, O., Fotsch, C.H., Reddy, P., McCarter, J.D.
Acs Chem.Biol.