CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.61
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

UniProtKB Entries (1)

Q40577
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase

PDB Structure

PDB 5IKA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
Koo, H.J., Vickery, C.R., Xu, Y., Louie, G.V., O'Maille, P.E., Bowman, M., Nartey, C.M., Burkart, M.D., Noel, J.P.
J.Antibiot.