CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.470.10
Functional Family Branched-chain-amino-acid aminotransferase

Enzyme Information

2.6.1.42
Branched-chain-amino-acid transaminase.
based on mapping to UniProt O15382
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

UniProtKB Entries (1)

O15382
BCAT2_HUMAN
Homo sapiens
Branched-chain-amino-acid aminotransferase, mitochondrial

PDB Structure

PDB 5I60
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.
Borthwick, J.A., Ancellin, N., Bertrand, S.M., Bingham, R.P., Carter, P.S., Chung, C.W., Churcher, I., Dodic, N., Fournier, C., Francis, P.L., Hobbs, A., Jamieson, C., Pickett, S.D., Smith, S.E., Somers, D.O., Spitzfaden, C., Suckling, C.J., Young, R.J.
J.Med.Chem.