CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1330.160
Functional Family

Enzyme Information

3.5.2.1
Barbiturase.
based on mapping to UniProt Q8RSQ2
Barbiturate + H(2)O = 3-oxo-3-ureidopropanoate.
-!- Specific for barbiturate as substrate. -!- Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 and EC 3.5.1.95. -!- It was previously thought that the end-products of the reaction were malonate and urea. -!- May be involved in the regulation of pyrimidine metabolism, along with EC 2.4.2.9.

UniProtKB Entries (1)

Q8RSQ2
BAR_RHOER
Rhodococcus erythropolis
Barbiturase

PDB Structure

PDB 5HXZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.
Peat, T.S., Balotra, S., Wilding, M., Hartley, C.J., Newman, J., Scott, C.
Appl. Environ. Microbiol.