CATH Domain 5hx6A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13546

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13546

RIPK1_HUMAN

Homo sapiens

Receptor-interacting serine/threonine-protein kinase 1

PDB Structure

PDB	5HX6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. Harris, P.A., King, B.W., Bandyopadhyay, D., Berger, S.B., Campobasso, N., Capriotti, C.A., Cox, J.A., Dare, L., Dong, X., Finger, J.N., Grady, L.C., Hoffman, S.J., Jeong, J.U., Kang, J., Kasparcova, V., Lakdawala, A.S., Lehr, R., McNulty, D.E., Nagilla, R., Ouellette, M.T., Pao, C.S., Rendina, A.R., Schaeffer, M.C., Summerfield, J.D., Swift, B.A., Totoritis, R.D., Ward, P., Zhang, A., Zhang, D., Marquis, R.W., Bertin, J., Gough, P.J. J.Med.Chem.