1 keywords

CATH Domain 5hneA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.10 D-amino Acid Aminotransferase; Chain A, domain 2
Homologous Superfamily 3.20.10.10 D-amino Acid Aminotransferase, subunit A, domain 2

Domain Context

CATH Clusters

Superfamily D-amino Acid Aminotransferase, subunit A, domain 2
Functional Family Branched-chain-amino-acid aminotransferase, mitochondrial

Enzyme Information

2.6.1.42
Branched-chain-amino-acid transaminase.
based on mapping to UniProt O15382
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

UniProtKB Entries (1)

O15382
BCAT2_HUMAN
Homo sapiens
Branched-chain-amino-acid aminotransferase, mitochondrial

PDB Structure

PDB 5HNE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.
Deng, H., Zhou, J., Sundersingh, F., Messer, J.A., Somers, D.O., Ajakane, M., Arico-Muendel, C.C., Beljean, A., Belyanskaya, S.L., Bingham, R., Blazensky, E., Boullay, A.B., Boursier, E., Chai, J., Carter, P., Chung, C.W., Daugan, A., Ding, Y., Herry, K., Hobbs, C., Humphries, E., Kollmann, C., Nguyen, V.L., Nicodeme, E., Smith, S.E., Dodic, N., Ancellin, N.
Acs Med.Chem.Lett.