CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P05364
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P05364
AMPC_ENTCL
Enterobacter cloacae
Beta-lactamase

PDB Structure

PDB 5HAI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine beta-Lactamases by Relieving Steric Strain.
Stojanoski, V., Adamski, C.J., Hu, L., Mehta, S.C., Sankaran, B., Zwart, P., Prasad, B.V., Palzkill, T.
Biochemistry