CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt Q5NH47
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

Q5NH47
CLPP_FRATT
Francisella tularensis subsp. tularensis SCHU S4
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 5G1S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Open and compressed conformations of Francisella tularensis ClpP.
Diaz-Saez, L., Pankov, G., Hunter, W.N.
Proteins