CATH Classification

Domain Context

CATH Clusters

Superfamily RIG-I-like receptor, C-terminal regulatory domain
Functional Family Probable ATP-dependent RNA helicase DDX58

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt O95786
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O95786
DDX58_HUMAN
Homo sapiens
Probable ATP-dependent RNA helicase DDX58

PDB Structure

PDB 5F98
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Devarkar, S.C., Wang, C., Miller, M.T., Ramanathan, A., Jiang, F., Khan, A.G., Patel, S.S., Marcotrigiano, J.
Proc.Natl.Acad.Sci.USA