CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.34
Plasma kallikrein.
based on mapping to UniProt P03952
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
-!- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. -!- Activates coagulation factors XII, VII and plasminogen. -!- Selective for Arg > Lys in P1, in small molecule substrates. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.21 and EC 3.4.21.8.

UniProtKB Entries (1)

P03952
KLKB1_HUMAN
Homo sapiens
Plasma kallikrein

PDB Structure

PDB 5F8T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M.
To Be Published