CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family Phosphatidylinositol 3-kinase, root isoform

Enzyme Information

2.7.1.137
Phosphatidylinositol 3-kinase.
based on mapping to UniProt Q8NEB9
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.

UniProtKB Entries (1)

Q8NEB9
PK3C3_HUMAN
Homo sapiens
Phosphatidylinositol 3-kinase catalytic subunit type 3

PDB Structure

PDB 5ENN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo
Kearney, E.P.
To Be Published