CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.480
Functional Family

Enzyme Information

1.13.11.52
Indoleamine 2,3-dioxygenase.
based on mapping to UniProt P14902
(1) D-tryptophan + O(2) = N-formyl-D-kynurenine. (2) L-tryptophan + O(2) = N-formyl-L-kynurenine.
-!- Requires ascorbic acid and methylene blue for activity. -!- Has broader substrate specificity than EC 1.13.11.11. -!- Is induced in response to pathological conditions and host-defense mechanisms. -!- While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. -!- Superoxide radicals can replace O(2) as oxygen donor.

UniProtKB Entries (1)

P14902
I23O1_HUMAN
Homo sapiens
Indoleamine 2,3-dioxygenase 1

PDB Structure

PDB 5EK4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
Peng, Y.H., Ueng, S.H., Tseng, C.T., Hung, M.S., Song, J.S., Wu, J.S., Liao, F.Y., Fan, Y.S., Wu, M.H., Hsiao, W.C., Hsueh, C.C., Lin, S.Y., Cheng, C.Y., Tu, C.H., Lee, L.C., Cheng, M.F., Shia, K.S., Shih, C., Wu, S.Y.
J.Med.Chem.