CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.360
Functional Family NAD(P)H dehydrogenase [quinone] 1

Enzyme Information

1.6.5.2
NAD(P)H dehydrogenase (quinone).
based on mapping to UniProt P15559
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.

UniProtKB Entries (1)

P15559
NQO1_HUMAN
Homo sapiens
NAD(P)H dehydrogenase [quinone] 1

PDB Structure

PDB 5EAI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.
Pidugu, L.S., Mbimba, J.C., Ahmad, M., Pozharski, E., Sausville, E.A., Emadi, A., Toth, E.A.
Bmc Struct.Biol.